You may have heard a lot of advice on boosting your immune health recently, but is boosting your immune system constantly the best course of action? Your immune system’s ‘fitness’ and resilience are far more essential to make sure you don’t tip the balance into a chronic inflammatory state. Here I will be discussing some of the ways you can ‘exercise’ your immune system to stay fit and healthy by focusing on a type of immune cell that plays as a peacekeeper, known as the regulatory T cells.
Why is immune fitness necessary?
One of your immune system’s vital functions is to regulate an appropriate immune response to molecules it comes into contact with by determining whether to initiate an inflammatory response against it. For example, on your skin, lungs and digestive tract, your immune cells will be exposed to food, bacteria, virus and pollutants, and it needs to make a decision: are these particles friend or foe? The correctness of this decision indicates your immune fitness.
If your immune system misses a trick, you may end up with a nasty infection, allowing the bad guys to take hold of the opportunistic situation. However, suppose your immune system wrongly accuses a particle of wrongdoings. In that case, you end up with a negative response to something that might be beneficial, such as food and self tissue, leading to food intolerances and autoimmunity.
On the other hand, once the immune response has been triggered, for example, after an injury, another critical job of the immune system is to make sure that it responds appropriately and in a timely fashion. The exactitude of this response reveals your immune resilience. Suppose your immune system stays switched on long after an inflammatory event. In that case, you are at risk of developing chronic illness, as low-grade systemic inflammation in your body contributes to damaging healthy cells, tissues and organs.
Regulation of your immune response
Regulatory T cells, also known as T regs, play a pivotal role in immune fitness and resilience. The balance between a pro and anti-inflammatory response is essential for your health and wellbeing, and these cells are critical at maintaining this equilibrium. T reg helps neutralise a pro-inflammatory immune response through several pathways to ensure chronic inflammation is not pursued.
An impaired regulatory response may arise for various reasons. Firstly, you may have a genetic susceptibility towards a pro-inflammatory state vs an anti-inflammatory state. However, as Mehmet Oz famously said, ‘your genetics load the gun. Your lifestyle pulls the trigger.’ So what lifestyle factors are at play? Many scientists believe that a person’s lack of exposure to dirt and pathogens as a child may cause an undeveloped immune system in adult life, often referred to as the hygiene hypothesis. This lack of exposure means that your immune system hasn’t had the training that it needs to be in top shape for its adulthood challenge.
Eating a standard western diet of high sugar and unhealthy fats may also impact your gut microbiome’s microbiota composition. Beneficial bacteria and microbes in your digestive tract produce immune-modulating compounds which promote the t reg response. Ensuring that you eat a diet rich in various dietary fibres that keep your gut microbiome thriving is central to regulating the immune system to keep it fit and healthy!
Obesity may also sway your body into a pro-inflammatory state as adipose tissue in itself is inflammatory releasing messengers known as cytokines to promote an inflammatory response. This effect of fat cells is why when someone loses weight, they often see improvements in their inflammatory symptoms.
So, how can you improve immune fitness & resilience?
If you do nothing else, having periods of fasting in your day and week could be the simplest way to start improving your immune fitness and resilience today. In a constant fed state, the t regs cannot properly develop and may cause a faulty and imbalanced immune system. Start with intermittent fasting, where you eat within a shortened eating window, such as 8 hours a day and then try either a partial fast or water fast for 1 – 5 days. Start with intermittent fasting where you eat within a shortened eating window, such as 8 hours a day and then try either a partial fast or water fast for 1 – 5 days.
Vitamin D deficiency may also impact the regulatory t cell response, so get your levels checked. If your levels are low, make sure you go outside, expose your skin to the sunlight for 20 minutes a day, eat vitamin D rich foods such as oily fish and egg yolks, or consider supplementing.
And lastly, if your body is stressed, nothing can function to its best, including your immune health. If you are struggling with stress, changes in mood or anxiety, then explore this first so you can build a robust immune system on solid foundations. Self-discovery and bringing joyful activities and people into your life are often significant first step to emotional healing.
So. the next time you recover from a cold, heal from a wound or feel full of energy, you can thank your immune system for its efforts and training. This silent system that works round the clock to keep you fit and healthy should receive this much-deserved recognition.
If you would like to take steps to improve your health today book your initial health assessment with me here, to start regaining your strength and feeling yourself again!
And find out more about the services we offer at The Autoimmunity Nutritionist clinic here.
- hOkada H, Kuhn C, Feillet H, Bach JF. The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. Clin Exp Immunol. 2010;160(1):1-9. doi:10.1111/j.1365-2249.2010.04139.x
- Makki K, Froguel P, Wolowczuk I. Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines. ISRN Inflamm. 2013;2013:139239. Published 2013 Dec 22. doi:10.1155/2013/139239
- Chapman NM, Chi H. mTOR signaling, Tregs and immune modulation. Immunotherapy. 2014;6(12):1295-1311. doi:10.2217/imt.14.84
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